Plasma Epstein-Barr virus DNA predicts outcome in advanced Hodgkin lymphoma: correlative analysis from a large North American cooperative group trial

Author:

Kanakry Jennifer A.1,Li Hailun2,Gellert Lan L.3,Lemas M. Victor1,Hsieh Wen-son4,Hong Fangxin2,Tan King L.5,Gascoyne Randy D.5,Gordon Leo I.6,Fisher Richard I.7,Bartlett Nancy L.8,Stiff Patrick9,Cheson Bruce D.10,Advani Ranjana11,Miller Thomas P.12,Kahl Brad S.13,Horning Sandra J.14,Ambinder Richard F.1

Affiliation:

1. Johns Hopkins University, School of Medicine, Baltimore, MD;

2. Dana Farber Cancer Institute, Harvard School of Public Health, Boston, MA;

3. Department of Pathology, Vanderbilt University Medical Center, Nashville, TN;

4. Cancer Sciences Institute of Singapore, National University of Singapore, Singapore;

5. British Columbia Cancer Agency, University of British Columbia, Center for Lymphoid Cancer, Vancouver, British Columbia, Canada;

6. Northwestern University, Feinberg School of Medicine, Robert H. Lurie Comprehensive Cancer Center, Chicago, IL;

7. University of Rochester James P. Wilmot Cancer Center, Rochester, NY;

8. Washington University Siteman Cancer Center, St. Louis, MO;

9. Loyola University Medical Center, Maywood, IL;

10. Georgetown University Center Hospital, Washington, DC;

11. Stanford University, Stanford, CA;

12. Division of Hematology and Medical Oncology, Arizona Cancer Center, Tucson, AZ;

13. University of Wisconsin, Madison, WI; and

14. Genentech, Inc, South San Francisco, CA

Abstract

Key Points Plasma EBV-DNA is highly concordant with EBV tumor status in Hodgkin lymphoma. Plasma EBV-DNA has prognostic significance in Hodgkin lymphoma, both before therapy and at month 6 of follow-up.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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