Accumulation of peripheral autoreactive B cells in the absence of functional human regulatory T cells-Reference-Cited by-同舟云学术

Accumulation of peripheral autoreactive B cells in the absence of functional human regulatory T cells

Published:2013-02-28 Issue:9 Volume:121 Page:1595-1603
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Kinnunen Tuure¹,Chamberlain Nicolas¹,Morbach Henner¹,Choi Jinyoung¹,Kim Sangtaek¹,Craft Joseph¹,Mayer Lloyd²,Cancrini Caterina³,Passerini Laura⁴,Bacchetta Rosa⁴,Ochs Hans D.⁵,Torgerson Troy R.⁵,Meffre Eric¹

Affiliation:

1. Department of Immunobiology, Yale University School of Medicine, New Haven, CT;

2. Department of Medicine, The Immunology Institute, Mount Sinai School of Medicine, New York, NY;

3. Department of Pediatrics (DPUO), Bambino Gesu Children's Hospital and University of Tor Vergata School of Medicine, Rome, Italy;

4. San Raffaele Telethon Institute for Gene Therapy (HSR-TIGET), Division of Regenerative Medicine, Stem Cells and Gene Therapy, San Raffaele Scientific Institute, Milan, Italy; and

5. Department of Pediatrics, University of Washington School of Medicine and Seattle Children's Research Institute, Seattle, WA

Abstract

Key Points Peripheral B-cell tolerance is defective in IPEX patients, suggesting that Tregs are involved in the maintenance of B-cell tolerance. T cells, including Tregs, display an activated phenotype in IPEX patients that may favor the accumulation of autoreactive B cells.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/121/9/1595/1368954/zh800913001595.pdf

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