TCR triggering modulates the responsiveness and homeostatic proliferation of CD4+ thymic emigrants to IL-7 therapy-Reference-Cited by-同舟云学术

TCR triggering modulates the responsiveness and homeostatic proliferation of CD4+ thymic emigrants to IL-7 therapy

Published:2013-06-06 Issue:23 Volume:121 Page:4684-4693
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Hennion-Tscheltzoff Olga¹²,Leboeuf Dominique¹,Gauthier Simon-David¹²,Dupuis Martine¹,Assouline Brigitte³,Grégoire Anne³,Thiant Stéphanie¹²,Guimond Martin¹²

Affiliation:

1. Maisonneuve-Rosemont Hospital Research Center, Montreal, QC, Canada;

2. Department of Microbiology-Immunology, Faculty of Medicine, University of Montreal, Montreal, QC, Canada; and

3. Cytheris SA, Issy-les-Moulineaux Cedex, France

Abstract

Key Points TCR stimulation increases IL-7 responsiveness. CD4+SPT proliferate more to IL-7 therapy.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/121/23/4684/1366583/4684.pdf

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4. TCR and IL-7 receptor signals can operate independently or synergize to promote lymphopenia-induced expansion of naive T cells.;Seddon;J Immunol,2002

5. Differential requirements for survival and proliferation of CD8 naïve or memory T cells.;Tanchot;Science,1997

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