Hierarchy in somatic mutations arising during genomic evolution and progression of follicular lymphoma-Reference-Cited by-同舟云学术

Hierarchy in somatic mutations arising during genomic evolution and progression of follicular lymphoma

Published:2013-02-28 Issue:9 Volume:121 Page:1604-1611
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Green Michael R.¹²,Gentles Andrew J.²³,Nair Ramesh V.²,Irish Jonathan M.¹⁴,Kihira Shingo¹,Liu Chih Long¹,Kela Itai¹,Hopmans Erik S.⁵,Myklebust June H.¹⁶,Ji Hanlee¹⁵,Plevritis Sylvia K.²³,Levy Ronald¹²,Alizadeh Ash A.¹²

Affiliation:

1. Division of Oncology, Department of Medicine,

2. Center for Cancer Systems Biology, and

3. Department of Radiology, Stanford University, Stanford, CA;

4. Department of Cancer Biology, School of Medicine, Vanderbilt University, Nashville, TN;

5. Genome Technology Center, Stanford University, Stanford, CA; and

6. Cancer Clinic, Department of Oncology, Oslo University Hospital, Oslo, Norway

Abstract

Key Points Analysis of coding genomes of FL tumor subpopulations reveals striking clonal diversity at diagnosis and progression. Within a hierarchy of somatic evolution of FL coding genomes, many recurrent mutations are subclonal at diagnosis.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/121/9/1604/1369059/zh800913001604.pdf

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