Targeting apoptosis to induce stable mixed hematopoietic chimerism and long-term allograft survival without myelosuppressive conditioning in mice-Reference-Cited by-同舟云学术

Targeting apoptosis to induce stable mixed hematopoietic chimerism and long-term allograft survival without myelosuppressive conditioning in mice

Published:2013-08-29 Issue:9 Volume:122 Page:1669-1677
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Cippà Pietro E.¹²,Gabriel Sarah S.¹²,Chen Jin¹²,Bardwell Philip D.³,Bushell Andrew⁴,Guimezanes Annick⁵,Kraus Anna K.¹²,Wekerle Thomas⁶,Wüthrich Rudolf P.¹²,Fehr Thomas¹²

Affiliation:

1. Institute of Physiology, University of Zürich, Zürich, Switzerland;

2. Division of Nephrology, University Hospital Zürich, Zürich, Switzerland;

3. Abbott Bioresearch Center, Worcester, MA;

4. Nuffield Department of Surgical Sciences, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom;

5. Centre d’Immunologie de Marseille-Luminy, Aix-Marseille Université, Marseille, France; and

6. Division of Transplantation, Medical University of Vienna, Vienna, Austria

Abstract

Key Points Immunological tolerance can be achieved by direct modulation of the intrinsic apoptosis pathway in peripheral lymphocytes.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/122/9/1669/1373515/1669.pdf

Reference47 articles.

1. Clinical experience with mixed chimerism to induce transplantation tolerance.;Fehr;Transpl Int,2008

2. Extrathymic T cell deletion and allogeneic stem cell engraftment induced with costimulatory blockade is followed by central T cell tolerance.;Wekerle;J Exp Med,1998

3. Mechanisms of transplant tolerance induction using costimulatory blockade.;Wekerle;Curr Opin Immunol,2002

4. Induced immune tolerance for kidney transplantation.;Scandling;N Engl J Med,2011

5. HLA-mismatched renal transplantation without maintenance immunosuppression.;Kawai;N Engl J Med,2008

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