SerpinB1 is critical for neutrophil survival through cell-autonomous inhibition of cathepsin G-Reference-Cited by-同舟云学术

SerpinB1 is critical for neutrophil survival through cell-autonomous inhibition of cathepsin G

Published:2013-05-09 Issue:19 Volume:121 Page:3900-3907
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Baumann Mathias¹²,Pham Christine T. N.³,Benarafa Charaf¹

Affiliation:

1. Theodor Kocher Institute and

2. Graduate School for Cellular and Biomedical Sciences, University of Bern, Bern, Switzerland; and

3. Division of Rheumatology, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO

Abstract

Key Points Serine protease inhibitor serpinB1 protects neutrophils by inhibition of their own azurophil granule protease cathepsin G. Granule permeabilization in neutrophils leads to cathepsin G–mediated death upstream and independent of apoptotic caspases.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/121/19/3900/1218553/3900.pdf

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