Inhibitory KIR/HLA incompatibility between sexual partners confers protection against HIV-1 transmission-Reference-Cited by-同舟云学术

Inhibitory KIR/HLA incompatibility between sexual partners confers protection against HIV-1 transmission

Published:2013-02-14 Issue:7 Volume:121 Page:1157-1164
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Jennes Wim¹,Verheyden Sonja²,Mertens Julie W.¹,Camara Makhtar³,Seydi Moussa⁴,Dieye Tandakha N.³,Mboup Souleymane³,Demanet Christian²,Kestens Luc¹⁵

Affiliation:

1. Laboratory of Immunology, Department of Biomedical Sciences, Institute of Tropical Medicine, Antwerp, Belgium;

2. HLA and Molecular Hematology Laboratory, Universitair Ziekenhuis Brussel (UZ Brussel), Brussels, Belgium;

3. Laboratory of Immunology, Department of Bacteriology-Virology, Centre Hospitalier Universitaire Le Dantec, Cheikh Anta Diop University, Dakar, Senegal;

4. Department of Infectious Diseases, Centre Hospitalier Universitaire Fann, Cheikh Anta Diop University, Dakar, Senegal; and

5. Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium

Abstract

Key Points HIV-1 transmission is influenced by the compatibility of sexual partners for two immune system genes, KIR and HLA. KIR/HLA incompatibility likely allows alloreactive NK cells from the exposed partner to reject incoming cells from the HIV-1–infected partner.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/121/7/1157/1367631/zh800713001157.pdf

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