Adjuvant facilitates tolerance induction to factor VIII in hemophilic mice through a Foxp3-independent mechanism that relies on IL-10-Reference-Cited by-同舟云学术

Adjuvant facilitates tolerance induction to factor VIII in hemophilic mice through a Foxp3-independent mechanism that relies on IL-10

Published:2013-05-09 Issue:19 Volume:121 Page:3936-3945
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Oliveira Vanessa G.¹²,Agua-Doce Ana¹²,Curotto de Lafaille Maria A.³,Lafaille Juan J.³,Graca Luis¹²

Affiliation:

1. Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal;

2. Instituto Gulbenkian de Ciência, Oeiras, Portugal; and

3. Skirball Institute of Biomolecular Medicine and Department of Pathology, New York University School of Medicine, New York, NY

Abstract

Key Points An adjuvant (alum), known to boost immune responses, can be used to facilitate a tolerogenic protocol. Nondepleting anti-CD4 can lead to Foxp3+ regulatory T-cell–independent tolerance that relies on IL-10.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/121/19/3936/1218700/3936.pdf

Reference48 articles.

1. Inhibitor development.;Astermark;Haemophilia,2008

2. The role of immunomodulation in the management of factor VIII inhibitors.;Lillicrap;Hematology (Am Soc Hematol Educ Program),2006

3. Immune tolerance therapy for factor VIII inhibitors: moving from empiricism to an evidence-based approach.;Dimichele;J Thromb Haemost,2007

4. Rituximab for adolescents with haemophilia and high titre inhibitors.;Fox;Haemophilia,2006

5. Immune tolerance therapy utilizing factor VIII/von Willebrand factor concentrate in haemophilia A patients with high titre factor VIII inhibitors.;Kurth;Haemophilia,2008

Cited by 12 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Modulation of CD4 T cell function via CD6-targeting;EBioMedicine;2019-09

2. Targeting Antigen-Specific B Cells Using Antigen-Expressing Transduced Regulatory T Cells;The Journal of Immunology;2018-07-18

3. Dexamethasone promotes durable factor VIII-specific tolerance in hemophilia A mice via thymic mechanisms;Haematologica;2018-04-19

4. Route of Antigen Presentation Can Determine the Selection of Foxp3-Dependent or Foxp3-Independent Dominant Immune Tolerance;The Journal of Immunology;2017-11-22

5. The Induction and Maintenance of Transplant Tolerance Engages Both Regulatory and Anergic CD4+ T cells;Frontiers in Immunology;2017-03-06