RhoA G17V is sufficient to induce autoimmunity and promotes T-cell lymphomagenesis in mice-Reference-Cited by-同舟云学术

RhoA G17V is sufficient to induce autoimmunity and promotes T-cell lymphomagenesis in mice

Published:2018-08-30 Issue:9 Volume:132 Page:935-947
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Ng Samuel Y.¹,Brown Leon¹,Stevenson Kristen²,deSouza Tiffany¹,Aster Jon C.³,Louissaint Abner⁴,Weinstock David M.¹⁵

Affiliation:

1. Department of Medical Oncology and

2. Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA;

3. Department of Pathology, Brigham and Women’s Hospital, Boston, MA;

4. Department of Pathology, Massachusetts General Hospital, Boston, MA; and

5. Broad Institute of MIT and Harvard University, Cambridge, MA

Abstract

Key Points Expression of RhoA G17V in CD4+ cells results in cellular and humoral autoimmunity. RhoA G17V expression with Tet2 loss induces T-cell lymphomas with features of AITL.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/132/9/935/1467299/blood818617.pdf

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