EBV-positive large B-cell lymphomas in young patients: a nodal lymphoma with evidence for a tolerogenic immune environment-Reference-Cited by-同舟云学术

EBV-positive large B-cell lymphomas in young patients: a nodal lymphoma with evidence for a tolerogenic immune environment

Published:2015-08-13 Issue:7 Volume:126 Page:863-872
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Nicolae Alina¹,Pittaluga Stefania¹^ORCID,Abdullah Shahed¹,Steinberg Seth M.²,Pham Thu Anh³,Davies-Hill Theresa¹,Xi Liqiang³,Raffeld Mark³,Jaffe Elaine S.¹^ORCID

Affiliation:

1. Hematopathology Section, Laboratory of Pathology, National Cancer Institute, Bethesda, MD;

2. Biostatistics and Data Management Section, Office of the Clinical Director, Center for Cancer Research, National Cancer Institute, Bethesda, MD; and

3. Molecular Diagnostics Unit, Laboratory of Pathology, National Cancer Institute, Bethesda, MD

Abstract

Key Points EBV+ LBCLs in young patients resemble those seen in the elderly, but usually have a good outcome. Tumor cells exhibit PD-L1 expression, with high indoleamine 2,3-dioxygenase–positive cell content, indications of a tolerogenic immune state.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/126/7/863/1390945/863.pdf

Reference45 articles.

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4. Epstein-Barr virus-positive diffuse large B-cell lymphoma in elderly patients is rare in Western populations.;Hoeller;Hum Pathol,2010

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