Aged murine hematopoietic stem cells drive aging-associated immune remodeling-Reference-Cited by-同舟云学术

Aged murine hematopoietic stem cells drive aging-associated immune remodeling

Published:2018-08-09 Issue:6 Volume:132 Page:565-576
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Leins Hanna¹²,Mulaw Medhanie³,Eiwen Karina²,Sakk Vadim²,Liang Ying⁴,Denkinger Michael⁵⁶,Geiger Hartmut²⁷,Schirmbeck Reinhold¹

Affiliation:

1. Department of Internal Medicine I, University Hospital of Ulm, Ulm, Germany;

2. Institute of Molecular Medicine, Stem Cell and Aging, Ulm University, Ulm, Germany;

3. Institute of Experimental Cancer Research, University Hospital of Ulm, Ulm, Germany;

4. Department of Toxicology and Cancer Biology, University of Kentucky, Lexington, KY;

5. AGAPLESION Bethesda Hospital, Geriatric Research Unit and

6. Geriatric Center Ulm/Alb-Donau, Ulm University, Ulm, Germany; and

7. Experimental Hematology and Cancer Biology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH

Abstract

Key Points Phenotypic and functional changes in T and B cells of old mice are primarily driven by aging of HSCs. CASIN-treated aged HSCs reconstitute an immune system with a function similar to that in young animals.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/132/6/565/1372790/blood831065.pdf

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4. Defective CD8 T cell responses in aged mice are due to quantitative and qualitative changes in virus-specific precursors;Decman;J Immunol,2012

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