Intravenous immunoglobulin vs observation in childhood immune thrombocytopenia: a randomized controlled trial-Reference-Cited by-同舟云学术

Intravenous immunoglobulin vs observation in childhood immune thrombocytopenia: a randomized controlled trial

Published:2018-08-30 Issue:9 Volume:132 Page:883-891
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Heitink-Pollé Katja M. J.¹²,Uiterwaal Cuno S. P. M.³,Porcelijn Leendert⁴,Tamminga Rienk Y. J.⁵,Smiers Frans J.⁶,van Woerden Nicole L.⁷,Wesseling Judit⁸,Vidarsson Gestur⁹¹⁰,Laarhoven Annemieke G.⁹¹⁰,de Haas Masja⁴⁹¹⁰¹¹,Bruin Marrie C. A.¹¹²

Affiliation:

1. Department of Pediatric Hematology, University Medical Center Utrecht, Utrecht, The Netherlands;

2. Department of Pediatrics, Flevo Hospital, Almere, The Netherlands;

3. Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands;

4. Department of Immunohematology Diagnostics, Sanquin Diagnostic Services, Amsterdam, The Netherlands;

5. Department of Pediatric Hematology and Oncology, University Medical Center Groningen, Groningen, The Netherlands;

6. Department of Pediatric Hematology, University Medical Center Leiden, Leiden, The Netherlands;

7. Department of Pediatrics, Meander Medical Center, Amersfoort, The Netherlands;

8. Department of Pediatrics, Rijnstate Hospital, Arnhem, The Netherlands;

9. Department of Experimental Immunohematology, Sanquin Research, and

10. Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands;

11. Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, The Netherlands; and

12. Princess Maxima Center for Pediatric Oncology, Utrecht, The Netherlands

Abstract

Key Points In children with newly diagnosed ITP, IVIg treatment at diagnosis does not result in a lower rate of chronic ITP. Upfront treatment with IVIg led to faster recovery and less severe bleeding events.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/132/9/883/1467193/blood830844.pdf

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