Hemostatic efficacy of pathogen-inactivated vs untreated platelets: a randomized controlled trial

Author:

van der Meer Pieter F.1ORCID,Ypma Paula F.12,van Geloven Nan3ORCID,van Hilten Joost A.1,van Wordragen-Vlaswinkel Rinie J.4,Eissen Okke2,Zwaginga Jaap J.4ORCID,Trus Michael5,Beckers Erik A. M.6,te Boekhorst Peter7ORCID,Tinmouth Alan8,Lin Yulia9ORCID,Hsia Cyrus10ORCID,Lee David11,Norris Philip J.12ORCID,Goodrich Raymond P.13ORCID,Brand Anneke14,Hervig Tor14ORCID,Heddle Nancy M.15,van der Bom Johanna G.116ORCID,Kerkhoffs Jean-Louis H.12ORCID

Affiliation:

1. Center for Clinical Transfusion Research–Sanquin, Leiden, The Netherlands;

2. Department of Hematology, HagaZiekenhuis, Den Haag, The Netherlands;

3. Department of Medical Statistics and Bioinformatics and

4. Department of Immunohematology and Blood Bank, Leiden University Medical Center, Leiden, The Netherlands;

5. Juravinsky Hospital, Hamilton, ON, Canada;

6. Maastricht University Medical Center, Maastricht, The Netherlands;

7. Erasmus Medical Center, Rotterdam, The Netherlands;

8. Ottawa Hospital, Ottawa, ON, Canada;

9. Sunnybrook Health Sciences Centre, Toronto, ON, Canada;

10. London Health Sciences Center, London, ON, Canada;

11. Kingston General Hospital, Kingston, ON, Canada;

12. Blood Systems Research Institute, San Francisco, CA;

13. Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO;

14. Haukeland University Hospital, Bergen, Norway;

15. Department of Medicine, McMaster University, Hamilton, ON, Canada; and

16. Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands

Abstract

Key Points Pathogen-inactivated platelets were noninferior in preventing bleeding only in intention-to-treat analysis. In contrast to animal models, alloimmunization could not be prevented when using pathogen-inactivated platelets.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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