SOX11 augments BCR signaling to drive MCL-like tumor development-Reference-Cited by-同舟云学术

SOX11 augments BCR signaling to drive MCL-like tumor development

Published:2018-05-17 Issue:20 Volume:131 Page:2247-2255
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Kuo Pei-Yu¹,Jatiani Shashidhar S.²^ORCID,Rahman Adeeb H.³⁴,Edwards Donna¹,Jiang Zewei¹,Ahr Katya¹,Perumal Deepak¹,Leshchenko Violetta V.¹,Brody Joshua¹,Shaknovich Rita⁵,Ye B. Hilda⁶,Parekh Samir¹

Affiliation:

1. Hematology and Medical Oncology,

2. Department of Pharmacological Sciences,

3. Human Immune Monitoring Core, and

4. Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY;

5. Division of Hematology/Oncology, Weill Cornell Medical College, New York, NY; and

6. Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY

Abstract

Key Points B-cell–specific overexpression of SOX11 promotes oncogenic proliferation of B1a B cells and drives an MCL-like phenotype. SOX11 overexpression is associated with increased signaling through the BCR pathway that can be reversed by pharmacological BTK inhibition.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/131/20/2247/1467821/blood832535.pdf

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