CD44 is a RAS/STAT5-regulated invasion receptor that triggers disease expansion in advanced mastocytosis

Author:

Mueller Niklas1ORCID,Wicklein Daniel2,Eisenwort Gregor13,Jawhar Mohamad4,Berger Daniela13,Stefanzl Gabriele13,Greiner Georg5,Boehm Alexandra1,Kornauth Christoph6,Muellauer Leonhard6,Sehner Susanne7,Hoermann Gregor35,Sperr Wolfgang R.13,Staber Philipp B.1,Jaeger Ulrich13,Zuber Johannes8,Arock Michel910,Schumacher Udo2,Reiter Andreas4,Valent Peter13

Affiliation:

1. Division of Hematology and Hemostaseology, Department of Internal Medicine I, Medical University of Vienna, Vienna, Austria;

2. Institute of Anatomy and Experimental Morphology, University Cancer Center, University Medical Center Hamburg-Eppendorf, Hamburg, Germany;

3. Ludwig Boltzmann Cluster Oncology, Medical University of Vienna, Vienna, Austria;

4. Department of Hematology and Oncology, University Hospital Mannheim, Mannheim, Germany;

5. Department of Laboratory Medicine and

6. Department of Pathology, Medical University of Vienna, Vienna, Austria;

7. Center for Experimental Medicine, Institute for Medical Biometry and Epidemiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany;

8. Research Institute of Molecular Pathology, Vienna, Austria;

9. Molecular and Cellular Oncology Unit, Centre National de la Recherche Scientifique UMR8113, Ecole Normale Supérieure de Cachan, Paris, France; and

10. Laboratory of Hematology, Pitié-Salpêtrière Hospital, Paris, France

Abstract

Key Points CD44 is a RAS/STAT5-dependent target in neoplastic mast cells and correlates with aggressiveness of mastocytosis. Depletion of CD44 in neoplastic mast cells is associated with reduced invasion and prolonged survival in SCID mice.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Reference97 articles.

1. Systemic mastocytosis;Austen;N Engl J Med,1992

2. Biology, classification and treatment of human mastocytosis;Valent;Wien Klin Wochenschr,1996

3. Mastocytosis: current concepts in diagnosis and treatment;Escribano;Ann Hematol,2002

4. Systemic mastocytosis;Akin;Annu Rev Med,2004

5. Diagnosis and classification of mast cell proliferative disorders: delineation from immunologic diseases and non-mast cell hematopoietic neoplasms;Valent;J Allergy Clin Immunol,2004

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