Oncogene-specific T cells fail to eradicate lymphoma-initiating B cells in mice

Author:

Hoser Dana123,Schön Christian1,Loddenkemper Christoph4,Lohneis Philipp5,Kühl Anja A.6,Sommermann Thomas7,Blankenstein Thomas178,Willimsky Gerald123

Affiliation:

1. Institute of Immunology, Charité–Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt–Universität zu Berlin, Berlin Institute of Health, Berlin, Germany;

2. German Cancer Research Center, Heidelberg, Germany;

3. German Cancer Consortium, partner site Berlin, Germany;

4. PathoTres, Praxis für Pathologie und Neuropathologie, Berlin, Germany;

5. Institute of Pathology, Charité–Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt–Universität zu Berlin, Berlin Institute of Health, Berlin, Germany;

6. iPATH.Berlin–Immunopathology for Experimental Models, Charité–Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt–Universität zu Berlin, Berlin Institute of Health, Berlin, Germany;

7. Max Delbrück Center for Molecular Medicine, Berlin, Germany; and

8. Berlin Institute of Health, Berlin, Germany

Abstract

Key PointsAbsence of oncogene-specific T cells leads to increased B-cell lymphoma incidence in a new mouse model. Premalignant lymphoma-initiating B cells are not eradicated by the immune system, retaining the risk of lymphoma development.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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