Resistance to CD19 Immunotherapy in B-Cell ALL Is Associated with Loss of CD19 and CD22 and an Enhanced Vulnerability to B Cell Receptor Signaling Inhibition

Author:

Aminov Sarah1,Giricz Orsi2,Sica R. Alejandro3,Polishchuk Veronika4,Yates Bonnie5,Wang Hao-Wei6,Wang Yanhua7,Sahu Srabani1,Gordon Shanisha1,Schinke Carolina8,Pradhan Kith9,Aluri Srinivas1,Janakiram Murali10,Barta Stefan K.11,Agarwal Beamon12,Goldfinger Mendel13,Shastri Aditi14,Matsui William15,Steidl Ulrich9,Brody Joshua16,Shah Nirali N.5,Parekh Samir17,Verma Amit18

Affiliation:

1. 1Blood Cancer Institute, Albert Einstein College of Medicine, Bronx, NY

2. 2Leukemia and Lymphoma Society, Rye Brook, NY

3. 3Montefiore Medical Center, New York City, NY

4. 4Division of Hematology/Oncology/BMT, Nationwide Children's Hospital, Columbus, OH

5. 5Pediatric Oncology Branch, National Cancer Institute/NIH, Bethesda, MD

6. 6Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD

7. 7Department of Pathology, Albert Einstein College of Medicine, Bronx, NY

8. 8Myeloma Center, Winthrop P. Rockefeller Institute, Department of Internal Medicine, University of Arkansas for Medical Sciences, Little Rock, AR

9. 9Albert Einstein College of Medicine, Bronx, NY

10. 10Division of Myeloma, Department of Hematology, City of Hope National Medical Center, Duarte, CA

11. 11Department of Medicine, Division of Hematology/Oncology, Hospital of the University of Pennsylvania, Philadelphia, PA

12. 12Department of Hematopathology, Montefiore Medical Center, New York, NY

13. 13Oncology, Montefiore Medical Center/ Albert Einstein College of Medicine, Bronx, NY

14. 14Oncology, Hematology/Oncology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY

15. 15MD Health Discovery, University of Texas, Austin, TX

16. 16Hematology and Medical Oncology, Mount Sinai School of Medicine, New York, NY

17. 17Department of Medicine, Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, NY

18. 18Department of Oncology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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