Response: common variable immunodeficiency patients with increased CD21−/lo B cells suffer from altered receptor editing and defective central B-cell tolerance
Author:
Affiliation:
1. Department of Pediatrics, Yale University School of Medicine, New Haven, CT
2. Department of Immunobiology, Yale University School of Medicine, New Haven, CT
3. Department of Medicine and Pediatrics, Mount Sinai Medical Center, New York, NY
Publisher
American Society of Hematology
Subject
Cell Biology,Hematology,Immunology,Biochemistry
Link
http://ashpublications.org/blood/article-pdf/118/22/5977/1345184/zh804811005977.pdf
Reference10 articles.
1. CD21low B cells in common variable immunodeficiency do not show defects in receptor editing, but resemble tissue-like memory B cells.;Rakhmanov;Blood,2010
2. Severe deficiency of switched memory B cells (CD27(+)IgM(-)IgD(-)) in subgroups of patients with common variable immunodeficiency: a new approach to classify a heterogeneous disease.;Warnatz;Blood,2002
3. Predominant autoantibody production by early human B-cell precursors.;Wardemann;Science,2003
4. Replication history of B lymphocytes reveals homeostatic proliferation and extensive antigen-induced B-cell expansion.;van Zelm;J Exp Med,2007
5. Circulating CD21low B cells in common variable immunodeficiency resemble tissue homing, innate-like B cells.;Rakhmanov;Proc Natl Acad Sci U S A,2009
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