Enhanced in utero allogeneic engraftment in mice after mobilizing fetal HSCs by α4β1/7 inhibition-Reference-Cited by-同舟云学术

Enhanced in utero allogeneic engraftment in mice after mobilizing fetal HSCs by α4β1/7 inhibition

Published:2016-11-17 Issue:20 Volume:128 Page:2457-2461
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Kim Aimee G.¹,Vrecenak Jesse D.¹,Boelig Matthew M.¹,Eissenberg Linda²,Rettig Michael P.²,Riley John S.¹,Holt Matthew S.²,Conner Michael A.¹,Loukogeorgakis Stavros P.¹,Li Haiying¹,DiPersio John F.²,Flake Alan W.¹,Peranteau William H.¹

Affiliation:

1. Center for Fetal Research, Children’s Hospital of Philadelphia, Philadelphia, PA; and

2. Division of Oncology, Washington University School of Medicine, St. Louis, MO

Abstract

Key Points CXCR4 and α4β1/7 inhibition by AMD3100 and firategrast mobilizes fetal liver HSCs with α4β1/7 inhibition having a stronger effect. Fetal HSC mobilization followed by IUHCT results in increased donor HSC homing to the FL and enhanced long-term allogeneic engraftment.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/128/20/2457/1396792/blood723981.pdf

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