Functional role and therapeutic targeting of p21-activated kinase 4 in multiple myeloma-Reference-Cited by-同舟云学术

Functional role and therapeutic targeting of p21-activated kinase 4 in multiple myeloma

Published:2017-04-20 Issue:16 Volume:129 Page:2233-2245
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Fulciniti Mariateresa¹,Martinez-Lopez Joaquin¹²,Senapedis William³,Oliva Stefania⁴,Lakshmi Bandi Rajya¹,Amodio Nicola⁵,Xu Yan¹,Szalat Raphael¹,Gulla Annamaria¹,Samur Mehmet K.¹,Roccaro Aldo¹⁶,Linares Maria²,Cea Michele¹⁷,Baloglu Erkan³,Argueta Christian³,Landesman Yosef³,Shacham Sharon³,Liu Siyuan⁸,Schenone Monica⁹,Wu Shiaw-Lin⁸,Karger Barry⁸,Prabhala Rao¹¹⁰,Anderson Kenneth C.¹,Munshi Nikhil C.¹¹⁰

Affiliation:

1. LeBow Institute for Myeloma Therapeutics and Jerome Lipper Multiple Myeloma Center, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA;

2. Hospital Universitario 12 de Octubre, Complutense School of Medicine, Spanish National Cancer Research Centre, Madrid, Spain;

3. Karyopharm Therapeutics Inc, Newton, MA;

4. Myeloma Unit, Division of Hematology, University of Turin, Italy;

5. Department of Experimental and Clinical Medicine, Magna Graecia University, Catanzaro, Italy;

6. CREA Laboratory, Department of Medical Oncology, ASST Spedali Civili di Brescia, Brescia, Italy;

7. Department of Medicine (DiMI), University of Genoa, Italy;

8. Barnett Institute, Northeastern University, Boston, MA;

9. Broad Institute, Cambridge, MA; and

10. VA Boston Healthcare System, Boston, MA

Abstract

Key Points High expression of PAK4 promotes myeloma cell proliferation through activation of MM antiapoptotic and survival pathways. Targeting PAK4 with a novel small molecule inhibitor, KPT-9274, has significant impact on MM cell growth and survival.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/129/16/2233/1399994/blood724831.pdf

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4. P21 activated kinases: structure, regulation, and functions;Rane;Small GTPases,2014

5. Cytoskeletal changes regulated by the PAK4 serine/threonine kinase are mediated by LIM kinase 1 and cofilin;Dan;J Biol Chem,2001

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