Nonneutralizing antibodies against factor VIII and risk of inhibitor development in severe hemophilia A-Reference-Cited by-同舟云学术

Nonneutralizing antibodies against factor VIII and risk of inhibitor development in severe hemophilia A

Published:2017-03-09 Issue:10 Volume:129 Page:1245-1250
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Cannavò Antonino¹,Valsecchi Carla¹,Garagiola Isabella²,Palla Roberta²,Mannucci Pier Mannuccio¹,Rosendaal Frits R.³,Peyvandi Flora¹²

Affiliation:

1. Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Fondazione Istituto Di Ricovero e Cura a Carattere Scientifico Ca’Granda Ospedale Maggiore Policlinico and Luigi Villa Foundation, Milan, Italy;

2. Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Milan, Italy; and

3. Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands

Abstract

Key Points Nonneutralizing antibodies against FVIII are detected in untreated or minimally treated patients with hemophilia A. The presence of nonneutralizing antibodies is associated with a substantially increased risk of inhibitor development.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/129/10/1245/1398670/blood720086.pdf

Reference50 articles.

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5. Risk stratification for inhibitor development at first treatment for severe hemophilia A: a tool for clinical practice;ter Avest;J Thromb Haemost,2008

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