Acquired expression of CblQ367P in mice induces dysplastic myelopoiesis mimicking chronic myelomonocytic leukemia

Author:

Nakata Yuichiro1,Ueda Takeshi2,Nagamachi Akiko3,Yamasaki Norimasa1,Ikeda Ken-ichiro1,Sera Yasuyuki1,Takubo Keiyo4,Kanai Akinori3,Oda Hideaki5,Sanada Masashi6,Ogawa Seishi6,Tsuji Kohichiro7,Ebihara Yasuhiro7,Wolff Linda8,Honda Zen-ichiro9,Suda Toshio10,Inaba Toshiya3,Honda Hiroaki1

Affiliation:

1. Department of Disease Model, Research Institute of Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan;

2. Department of Biochemistry, Faculty of Medicine, Kindai University, Osaka, Japan;

3. Department of Molecular Oncology, Research Institute of Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan;

4. Department of Stem Cell Biology, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan;

5. Department of Pathology, Tokyo Women’s Medical University, Tokyo, Japan;

6. Department of Pathology, Graduate School of Medicine, Kyoto University, Kyoto, Japan;

7. Division of Cellular Therapy, Advanced Clinical Research Center, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan;

8. Laboratory of Cellular Oncology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD;

9. Health Service Center, Ochanomizu University, Tokyo, Japan; and

10. Cancer Science Institute of Singapore, Center for Translational Medicine, National University of Singapore, Singapore

Abstract

Key Points Acquired expression of CblQ367P induces sustained proliferation of myelomonocytes, multilineage dysplasia, and splenomegaly resembling CMML. Combined inhibition of PI3K and JAK2 efficiently suppressed the growth of CblQ367P-induced CMML cells.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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