miR-125b promotes MLL-AF9–driven murine acute myeloid leukemia involving a VEGFA-mediated non–cell-intrinsic mechanism-Reference-Cited by-同舟云学术

miR-125b promotes MLL-AF9–driven murine acute myeloid leukemia involving a VEGFA-mediated non–cell-intrinsic mechanism

Published:2017-03-16 Issue:11 Volume:129 Page:1491-1502
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Liu Jun¹²,Guo Bo¹²³,Chen Zhuo¹²⁴,Wang Nayi¹²⁴,Iacovino Michelina⁵,Cheng Jijun¹²,Roden Christine¹²,Pan Wen¹²,Khan Sajid⁶,Chen Suning⁷,Kyba Michael⁸,Fan Rong²⁴,Guo Shangqin²⁵,Lu Jun¹²⁹

Affiliation:

1. Department of Genetics, Yale University School of Medicine, New Haven, CT;

2. Yale Stem Cell Center, Yale Cancer Center, New Haven, CT;

3. Chinese People's Liberation Army General Hospital, Beijing, China;

4. Department of Biomedical Engineering, Yale University, New Haven, CT;

5. Department of Cell Biology, and

6. Department of Surgery, Yale University School of Medicine, New Haven, CT;

7. Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, China;

8. Lillehei Heart Institute and Department of Pediatrics, University of Minnesota, Minneapolis, MN; and

9. Yale Center for RNA Science and Medicine, New Haven, CT

Abstract

Key Points miR-125b overexpression accelerates MLL-AF9–driven AML and endows partial addiction to its overexpression. A miR-125b-TET2-VEGFA pathway promotes leukemogenesis involving a non–cell-intrinsic mechanism.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/129/11/1491/1399216/blood721027.pdf

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