The prognostic value of multiparametric flow cytometry in AL amyloidosis at diagnosis and at the end of first-line treatment

Author:

Muchtar Eli1ORCID,Jevremovic Dragan2,Dispenzieri Angela1,Dingli David1,Buadi Francis K.1,Lacy Martha Q.1,Gonsalves Wilson1,Hayman Suzanne R.1,Kapoor Prashant1,Leung Nelson123,Russell Stephen1,Lust John A.1,Lin Yi1,Go Ronald S.1,Chakraborty Rajshekhar14,Zeldenrust Steven1,Kumar Shaji K.1,Kyle Robert A.1,Rajkumar S. Vincent1,Gertz Morie A.1ORCID

Affiliation:

1. Division of Hematology,

2. Division of Hematopathology, Department of Laboratory Medicine and Pathology, and

3. Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN; and

4. Hospitalist Services, Essentia Health St. Joseph's Hospital, Brainerd, MN

Abstract

Key Points The monotypic and polytypic PC compartments assessed by MFC are prognostic in AL amyloidosis. MFC may play a role in the definition of hematologic response to treatment.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Reference18 articles.

1. Flow cytometry in hematological nonmalignant disorders;Béné;Int J Lab Hematol,2016

2. Diverse niches within multiple myeloma bone marrow aspirates affect plasma cell enumeration;Nadav;Br J Haematol,2006

3. Role of Flow Cytometry in the Diagnosis and Prognosis of Plasma Cell Myeloma;Olteanu;Surg Pathol Clin,2016

4. New criteria for response assessment: role of minimal residual disease in multiple myeloma;Paiva;Blood,2015

5. Immunophenotypic analysis of abnormal plasma cell clones in bone marrow of primary systemic light chain amyloidosis patients;Hu;Chinese Med J,2014

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