Human CalDAG-GEFI deficiency increases bleeding and delays αIIbβ3 activation-Reference-Cited by-同舟云学术

Human CalDAG-GEFI deficiency increases bleeding and delays αIIbβ3 activation

Published:2016-12-08 Issue:23 Volume:128 Page:2729-2733
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Kato Hisashi¹,Nakazawa Yozo²,Kurokawa Yumi³,Kashiwagi Hirokazu¹,Morikawa Yoichiro¹,Morita Daisuke²,Banno Fumiaki⁴,Honda Shigenori⁵,Kanakura Yuzuru¹,Tomiyama Yoshiaki⁶

Affiliation:

1. Department of Hematology and Oncology, Osaka University Graduate School of Medicine, Osaka, Japan;

2. Department of Pediatrics, and

3. Department for the Promotion of Regional Medicine, Shinshu University School of Medicine, Matsumoto, Japan;

4. Department of Food and Nutrition, Koriyama Women’s University, Koriyama, Japan;

5. Department of Molecular Pathogenesis, National Cerebral and Cardiovascular Center, Suita, Japan; and

6. Department of Blood Transfusion, Osaka University Hospital, Osaka, Japan

Abstract

Key Points In human CalDAG-GEFI deficiency, αIIbβ3 activation was impaired, but not agonist-induced neutrophil β2 integrin activation. Delayed αIIbβ3 activation kinetics was associated with severe bleeding tendency in CalDAG-GEFI deficiency.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/128/23/2729/1397519/blood704825.pdf

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