Hedgehog pathway activation in T-cell acute lymphoblastic leukemia predicts response to SMO and GLI1 inhibitors-Reference-Cited by-同舟云学术

Hedgehog pathway activation in T-cell acute lymphoblastic leukemia predicts response to SMO and GLI1 inhibitors

Published:2016-12-08 Issue:23 Volume:128 Page:2642-2654
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Dagklis Antonis¹²,Demeyer Sofie¹²,De Bie Jolien¹²,Radaelli Enrico¹²,Pauwels Daphnie¹²,Degryse Sandrine¹²,Gielen Olga¹²,Vicente Carmen¹²,Vandepoel Roel¹²,Geerdens Ellen¹²,Uyttebroeck Anne³,Boeckx Nancy⁴⁵,de Bock Charles E.¹²,Cools Jan¹²

Affiliation:

1. KU Leuven Center for Human Genetics, Leuven, Belgium;

2. VIB Center for the Biology of Disease, Leuven, Belgium;

3. Pediatric Oncology and

4. Department of Laboratory Medicine, UZ Leuven, Leuven, Belgium; and

5. Department of Oncology, KU Leuven, Leuven, Belgium

Abstract

Key Points A subset of T-ALL cases show high expression of hedgehog pathway genes including the SHH ligand and the GLI1 transcription factor. T-ALL samples with high GLI1 expression levels respond to hedgehog inhibitor treatment in vitro and in vivo.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/128/23/2642/1397416/blood703454.pdf

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