Chemo-genomic interrogation of CEBPA mutated AML reveals recurrent CSF3R mutations and subgroup sensitivity to JAK inhibitors-Reference-Cited by-同舟云学术

Chemo-genomic interrogation of CEBPA mutated AML reveals recurrent CSF3R mutations and subgroup sensitivity to JAK inhibitors

Published:2016-06-16 Issue:24 Volume:127 Page:3054-3061
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Lavallée Vincent-Philippe¹²^ORCID,Krosl Jana¹,Lemieux Sébastien¹³^ORCID,Boucher Geneviève¹^ORCID,Gendron Patrick¹,Pabst Caroline¹^ORCID,Boivin Isabel¹,Marinier Anne¹⁴,Guidos Cynthia J.⁵⁶,Meloche Sylvain⁷⁸,Hébert Josée¹²⁹¹⁰,Sauvageau Guy¹²⁹¹⁰

Affiliation:

1. The Leucegene Project at Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, QC, Canada;

2. Division of Hematology, Maisonneuve-Rosemont Hospital, Montréal, QC, Canada;

3. Department of Computer Science and Operations Research, and

4. Department of Chemistry, Université de Montréal, Montréal, QC, Canada;

5. Program in Developmental and Stem Cell Biology, Hospital for Sick Children Research Institute, Toronto, ON, Canada;

6. Department of Immunology, University of Toronto, Toronto, ON, Canada;

7. Department of Pharmacology, and

8. Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, QC, Canada;

9. Quebec Leukemia Cell Bank, Maisonneuve-Rosemont Hospital, Montréal, QC, Canada; and

10. Department of Medicine, Faculty of Medicine, Université de Montréal, Montréal, QC, Canada

Abstract

Key Points CSF3R was the most frequently mutated gene identified in this CEBPAbi AML cohort analyzed by next-generation sequencing. CEBPA bi AML that have a characteristic transcriptomic profile are more sensitive to JAK inhibitors than CEBPAwt AML.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/127/24/3054/1393842/3054.pdf

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