Genome-wide analysis of pediatric-type follicular lymphoma reveals low genetic complexity and recurrent alterations of TNFRSF14 gene

Author:

Schmidt Janine1,Gong Shunyou2,Marafioti Teresa3,Mankel Barbara1,Gonzalez-Farre Blanca4,Balagué Olga4,Mozos Ana5,Cabeçadas José6,van der Walt Jon7,Hoehn Daniela8,Rosenwald Andreas9,Ott German10,Dojcinov Stefan11,Egan Caoimhe2,Nadeu Ferran4,Ramis-Zaldívar Joan Enric4,Clot Guillem4,Bárcena Carmen12,Pérez-Alonso Vanesa12,Endris Volker13,Penzel Roland13,Lome-Maldonado Carmen14,Bonzheim Irina1,Fend Falko1,Campo Elias4,Jaffe Elaine S.2,Salaverria Itziar4,Quintanilla-Martinez Leticia1

Affiliation:

1. Institute of Pathology and Neuropathology, Eberhard Karls University of Tübingen and Comprehensive Cancer Center, University Hospital Tübingen, Tübingen, Germany;

2. Hematopathology Section, Laboratory of Pathology, National Cancer Institute, Bethesda, MD;

3. Department of Cellular Pathology, Barts and The London NHS Trust, London, United Kingdom;

4. Hematopathology Unit, Hospital Clínic, Institut d’Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain;

5. Pathology Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain;

6. Pathology Department, Instituto Portugues de Oncología, Lisboa, Portugal;

7. Department of Histopathology, Guy’s and St. Thomas Hospitals, London, United Kingdom;

8. Department of Pathology and Cell Biology, Columbia University Medical Center, New York, NY;

9. Institute of Pathology, University of Würzburg, and Comprehensive Cancer Center Mainfranken, Würzburg, Germany;

10. Department of Clinical Pathology, Robert-Bosch-Hospital and Dr Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany;

11. Department of Pathology, All Wales Lymphoma Panel, University Hospital of Wales, Cardiff, United Kingdom;

12. Hospital Universitario 12 de Octubre, Madrid, Spain;

13. Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany; and

14. Department of Pathology, Instituto Nacional de Cancerologia, Mexico City, Mexico

Abstract

Key Points PTFL is a monoclonal B-cell neoplasia with low genomic complexity and recurrent TNFRSF14 mutations/deletions. The genetic profiles of conventional t(14;18)− and t(14;18)+ FL are similar but distinct from PTFL.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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