Maternal extracellular vesicles and platelets promote preeclampsia via inflammasome activation in trophoblasts

Author:

Kohli Shrey1,Ranjan Satish1,Hoffmann Juliane1,Kashif Muhammed2,Daniel Evelyn A.13,Al-Dabet Moh'd Mohanad1,Bock Fabian1,Nazir Sumra1,Huebner Hanna4,Mertens Peter R.5,Fischer Klaus-Dieter6,Zenclussen Ana C.7,Offermanns Stefan8,Aharon Anat9,Brenner Benjamin9,Shahzad Khurrum110,Ruebner Matthias4,Isermann Berend1

Affiliation:

1. Institute of Clinical Chemistry and Pathobiochemistry, Otto von Guericke University, Magdeburg, Germany;

2. Centre for Thrombosis and Hemostasis, University Medical Center Mainz, Mainz, Germany;

3. Institute of Neuropathology, Otto von Guericke University, Magdeburg, Germany;

4. Department of Gynaecology and Obstetrics, Laboratory for Molecular Medicine, University-Clinic Erlangen, Erlangen, Germany;

5. Department of Nephrology and Hypertension, Diabetes and Endocrinology,

6. Institute of Biochemistry and Cell Biology and Department of Functional Genomics and Medical Toponomics, and

7. Experimental Obstetrics and Gynecology, Medical Faculty, Otto von Guericke University, Magdeburg, Germany;

8. Department of Pharmacology, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany;

9. Department of Hematology, Rambam Health Care Campus, Haifa, Israel; and

10. Department of Molecular Genetics, University of Health Sciences, Khayaban-e-Jamia Punjab, Lahore, Pakistan

Abstract

Key Points EVs cause accumulation of activated maternal platelets within the placenta, resulting in a thromboinflammatory response and PE. Activated maternal platelets cause NLRP3-inflammasome activation in trophoblast cells via ATP release and purinergic signaling.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Reference65 articles.

1. Pregnancy-related mortality from preeclampsia and eclampsia.;MacKay;Obstet Gynecol,2001

2. Preeclampsia, a disease of the maternal endothelium: the role of antiangiogenic factors and implications for later cardiovascular disease.;Powe;Circulation,2011

3. Pre-eclampsia.;Steegers;Lancet,2010

4. Expression of lipoxin A4, TNFα and IL-1β in maternal peripheral blood, umbilical cord blood and placenta, and their significance in pre-eclampsia.;Dong;Hypertens Pregnancy,2014

5. Hypertension in pregnancy. Report of the American College of Obstetricians and Gynecologists’ Task Force on Hypertension in Pregnancy.;American College of Obstetricians and Gynecologists; Task Force on Hypertension in Pregnancy;Obstet Gynecol,2013

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