Hyperfibrinolysis increases blood–brain barrier permeability by a plasmin- and bradykinin-dependent mechanism-Reference-Cited by-同舟云学术

Hyperfibrinolysis increases blood–brain barrier permeability by a plasmin- and bradykinin-dependent mechanism

Published:2016-11-17 Issue:20 Volume:128 Page:2423-2434
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Marcos-Contreras Oscar A.¹,Martinez de Lizarrondo Sara¹,Bardou Isabelle¹,Orset Cyrille¹,Pruvost Mathilde¹,Anfray Antoine¹,Frigout Yvann¹,Hommet Yannick¹,Lebouvier Laurent¹,Montaner Joan²,Vivien Denis¹³,Gauberti Maxime¹⁴

Affiliation:

1. INSERM Unité 919, Serine Proteases and Pathophysiology of the Neurovascular Unit, Cyceron, Université de Caen Normandy (UNICAEN) Caen, France;

2. Neurovascular Research Laboratory, Vall d'Hebron Research Institute, Barcelona, Spain;

3. Department of Cell Biology, and

4. Department of Diagnostic Imaging and Interventional Radiology, Medical Center, Caen University Hospital, Caen, France

Abstract

Key Points Hydrodynamic transfection of plasmids encoding for plasminogen activators leads to a hyperfibrinolytic state in mice. Hyperfibrinolysis increases BBB permeability via a plasmin- and bradykinin-dependent mechanism.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/128/20/2423/1397103/blood705384.pdf

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