Reduced frequency of circulating CD4+CD25brightCD127lowFOXP3+ regulatory T cells in primary myelofibrosis

Author:

Massa Margherita1,Campanelli Rita2,Fois Gabriela2,Villani Laura2,Bonetti Elisa2,Catarsi Paolo2,Poletto Valentina2,Viarengo Gianluca3,De Amici Mara4,Rosti Vittorio2,Gale Robert Peter5,Barosi Giovanni2

Affiliation:

1. Biotechnology Research Area,

2. Center for the Study of Myelofibrosis, Biotechnology Research Area,

3. Immunohematology and Transfusion Service, and

4. Division of Pediatrics, Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo Foundation, Pavia, Italy; and

5. Haematology Research Centre, Division of Haematology, Department of Medicine, Imperial College London, London, United Kingdom

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Reference26 articles.

1. An immune dysregulation in MPN.;Barosi;Curr Hematol Malig Rep,2014

2. Development and function of CD25+CD4+ regulatory T cells.;Fehérvari;Curr Opin Immunol,2004

3. Human CD4+ CD25+ regulatory T cells suppress NKT cell functions.;Azuma;Cancer Res,2003

4. CD4+CD25+ regulatory T cells down-regulate co-stimulatory molecules on antigen-presenting cells.;Cederbom;Eur J Immunol,2000

5. CD4+CD25+ T(R) cells suppress innate immune pathology through cytokine-dependent mechanisms.;Maloy;J Exp Med,2003

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