Human neutrophil kinetics: modeling of stable isotope labeling data supports short blood neutrophil half-lives-Reference-Cited by-同舟云学术

Human neutrophil kinetics: modeling of stable isotope labeling data supports short blood neutrophil half-lives

Published:2016-06-30 Issue:26 Volume:127 Page:3431-3438
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Lahoz-Beneytez Julio¹²,Elemans Marjet²,Zhang Yan³,Ahmed Raya³,Salam Arafa³,Block Michael¹,Niederalt Christoph¹,Asquith Becca²^ORCID,Macallan Derek³⁴^ORCID

Affiliation:

1. Computational Systems Biology, Bayer Technology Services GmbH, Leverkusen, Germany;

2. Theoretical Immunology Group, Faculty of Medicine, Imperial College London, London, United Kingdom;

3. Institute for Infection and Immunity, St George’s, University of London, London, United Kingdom; and

4. St George’s University Hospitals NHS Foundation Trust, London, United Kingdom

Abstract

Key Points Mechanistic modeling of stable isotope labeling verifies human neutrophil half-lives of 13-19 h in contrast to recent estimates of >3 days. Human neutrophil kinetics can be measured using a single-dose deuterium-labeled glucose protocol.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/127/26/3431/1394542/3431.pdf

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4. What’s your age again? Determination of human neutrophil half-lives revisited.;Tak;J Leukoc Biol,2013

5. Neutrophil kinetics in man.;Dancey;J Clin Invest,1976

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