The bulk of the hematopoietic stem cell population is dispensable for murine steady-state and stress hematopoiesis

Author:

Schoedel Kristina B.1,Morcos Mina N. F.1,Zerjatke Thomas2,Roeder Ingo2,Grinenko Tatyana3,Voehringer David4,Göthert Joachim R.5,Waskow Claudia6,Roers Axel1,Gerbaulet Alexander1

Affiliation:

1. Institute for Immunology,

2. Institute for Medical Informatics and Biometry, and

3. Department for Clinical Pathobiochemistry, Institute of Clinical Chemistry and Laboratory Medicine, Carl Gustav Carus Faculty of Medicine, Technische Universität Dresden, Dresden, Germany;

4. Department of Infection Biology, University Hospital Erlangen, Erlangen, Germany;

5. Department of Hematology, University Hospital of Essen, Essen, Germany; and

6. Regeneration in Hematopoiesis, Institute for Immunology, Carl Gustav Carus Faculty of Medicine, Technische Universität Dresden, Dresden, Germany

Abstract

Key Points After induced HSPC depletion, HSC numbers remain at low levels whereas progenitors show robust recovery. Despite low HSC numbers, hematopoiesis proceeds normally without increased proliferation of the few residual HSCs.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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