Germ line variants predispose to both JAK2 V617F clonal hematopoiesis and myeloproliferative neoplasms-Reference-Cited by-同舟云学术

Germ line variants predispose to both JAK2 V617F clonal hematopoiesis and myeloproliferative neoplasms

Published:2016-08-25 Issue:8 Volume:128 Page:1121-1128
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Hinds David A.¹,Barnholt Kimberly E.¹,Mesa Ruben A.²,Kiefer Amy K.¹,Do Chuong B.¹,Eriksson Nicholas¹,Mountain Joanna L.¹,Francke Uta¹,Tung Joyce Y.¹,Nguyen Huong (Marie)³,Zhang Haiyu⁴,Gojenola Linda⁴,Zehnder James L.⁴⁵,Gotlib Jason⁵

Affiliation:

1. 23andMe, Inc, Mountain View, CA;

2. Division of Hematology & Medical Oncology, Mayo Clinic, Scottsdale, AZ;

3. Division of Hematology/Oncology, University of Michigan Comprehensive Cancer Center, Ann Arbor, MI;

4. Department of Pathology, Stanford University School of Medicine, Stanford, CA; and

5. Division of Hematology, Department of Medicine, Stanford University School of Medicine/Stanford Cancer Institute, Stanford, CA

Abstract

Key Points Germ line variants in TERT, SH2B3, TET2, ATM, CHEK2, PINT, and GFI1B are associated with JAK2 V617F clonal hematopoiesis and MPNs. Age-related JAK2 V617F clonal hematopoiesis is found in ∼2 out of 1000 individuals in the general population.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/128/8/1121/1465033/1121.pdf

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