slan-defined subsets of CD16-positive monocytes: impact of granulomatous inflammation and M-CSF receptor mutation

Author:

Hofer Thomas P.1,Zawada Adam M.2,Frankenberger Marion1,Skokann Kerstin1,Satzl Anna A.3,Gesierich Wolfgang3,Schuberth Madeleine4,Levin Johannes4,Danek Adrian4,Rotter Björn5,Heine Gunnar H.2,Ziegler-Heitbrock Loems1

Affiliation:

1. The EvA Study Center, Comprehensive Pneumology Center, Helmholtz-Zentrum München, Gauting, Germany;

2. Department of Internal Medicine IV, Nephrology and Hypertension, Saarland University Medical Center, Homburg, Germany;

3. Asklepios Fachklinik München-Gauting, German Center for Lung Research, Gauting, Germany;

4. Neurologische Klinik und Poliklinik, Ludwig-Maximilians-Universität, München, Germany; and

5. GenXPro, Frankfurt, Germany

Abstract

Key Points The slan marker can be used to define nonclassical and intermediate monocytes in human blood. slan-negative intermediate monocytes are expanded in sarcoidosis, and slan-positive nonclassical monocytes are depleted in HDLS.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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