1. Department of Internal Medicine III, University Hospital Ulm, Ulm, Germany;
2. Department of Internal Medicine II, University Hospital Würzburg, Würzburg, Germany;
3. Department of Hematology, Oncology, and Pneumology, Johannes Gutenberg-University, Mainz, Germany;
4. Medical Department II, University Hospital Schleswig Holstein Campus Kiel, Kiel, Germany;
5. Klinik für Innere Medizin I, Saarland University Medical School, Homburg (Saar), Germany;
6. University Hospital Göttingen, Göttingen, Germany;
7. Department of Radiology, Diakoniekrankenhaus Schwäbisch-Hall, Schwäbisch-Hall, Germany;
8. Amgen Research (Munich), Munich, Germany;
9. Amgen Inc, Thousand Oaks, CA; and
10. Comprehensive Cancer Center Mainfranken, University Hospital Würzburg, Würzburg, Germany