Gnb isoforms control a signaling pathway comprising Rac1, Plcβ2, and Plcβ3 leading to LFA-1 activation and neutrophil arrest in vivo-Reference-Cited by-同舟云学术

Gnb isoforms control a signaling pathway comprising Rac1, Plcβ2, and Plcβ3 leading to LFA-1 activation and neutrophil arrest in vivo

Published:2016-01-21 Issue:3 Volume:127 Page:314-324
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Block Helena¹,Stadtmann Anika¹,Riad Daniel¹,Rossaint Jan¹,Sohlbach Charlotte¹,Germena Giulia¹,Wu Dianqing²,Simon Scott I.³,Ley Klaus⁴,Zarbock Alexander¹

Affiliation:

1. Department of Anaesthesiology, Intensive Care and Pain Medicine, University of Muenster, Muenster, Germany;

2. Department of Pharmacology and Vascular Biology, Yale University, New Haven, CT;

3. Department of Biomedical Engineering, University of California, Davis, CA; and

4. La Jolla Institute for Allergy and Immunology, La Jolla, CA

Abstract

Key Points Gnb isoforms are centrally involved in Rac1-dependent chemokine-induced LFA-1 activation. Plcβ2 and Plcβ3 function nonredundantly to produce inositol triphosphate with subsequent calcium flux leading to LFA-1 activation.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/127/3/314/1393596/314.pdf

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