Cord blood T cells mediate enhanced antitumor effects compared with adult peripheral blood T cells-Reference-Cited by-同舟云学术

Cord blood T cells mediate enhanced antitumor effects compared with adult peripheral blood T cells

Published:2015-12-24 Issue:26 Volume:126 Page:2882-2891
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Hiwarkar Prashant¹²,Qasim Waseem¹³,Ricciardelli Ida¹,Gilmour Kimberly⁴,Quezada Sergio⁵,Saudemont Aurore⁶⁷,Amrolia Persis¹⁸,Veys Paul¹⁸

Affiliation:

1. Molecular and Cellular Immunology Section, University College London Institute of Child Health, London, United Kingdom;

2. Department of Haematology and Bone Marrow transplantation, Birmingham Children’s Hospital, Birmingham, United Kingdom;

3. Department of Immunology and

4. Laboratory Immunology, Great Ormond Street Hospital for Children, London, United Kingdom;

5. Department of Haematology, University College London Cancer Institute, London, United Kingdom;

6. Anthony Nolan Research Institute, London, United Kingdom;

7. Cancer Institute, University College London, London, United Kingdom; and

8. Department of Bone Marrow Transplantation, Great Ormond Street Hospital for Children, London, United Kingdom

Abstract

Key Points CB T cells mediate enhanced antitumor responses compared with PB T cells in a murine model of B-cell lymphoma. The antitumor activity correlates with increased tumor-homing of CCR7high CB CD8+ T cells and rapid gain of cytotoxic and Th1 function.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/126/26/2882/1391141/2882.pdf

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