CD20+ B-cell depletion therapy suppresses murine CD8+ T-cell–mediated immune thrombocytopenia-Reference-Cited by-同舟云学术

CD20+ B-cell depletion therapy suppresses murine CD8+ T-cell–mediated immune thrombocytopenia

Author:

Guo Li¹²,Kapur Rick¹³,Aslam Rukshana¹,Speck Edwin R.¹,Zufferey Anne¹,Zhao Yajing¹,Kim Michael¹,Lazarus Alan H.¹²³⁴⁵,Ni Heyu¹²³⁴⁵,Semple John W.¹²³⁴⁵

Affiliation:

1. The Toronto Platelet Immunobiology Group, Keenan Research Centre for Biomedical Science of St. Michael’s Hospital, Toronto, ON, Canada;

2. Institute of Medical Science, University of Toronto, Toronto, ON, Canada;

3. Canadian Blood Services, Toronto, ON, Canada; and

4. Department of Medicine,

5. Department of Laboratory Medicine and Pathobiology, and

Abstract

Key Points CD20 Bdep therapy inhibits CD8+ T-cell proliferation in vitro. CD20 Bdep therapy prevents CD8+ T-cell–mediated ITP in vivo.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

Reference25 articles.

2. Demonstration of a thrombocytopenic factor in the blood of patients with thrombocytopenic purpura.;Harrington;J Lab Clin Med,1951

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