Targeting of the bone marrow microenvironment improves outcome in a murine model of myelodysplastic syndrome-Reference-Cited by-同舟云学术

Targeting of the bone marrow microenvironment improves outcome in a murine model of myelodysplastic syndrome

Published:2016-02-04 Issue:5 Volume:127 Page:616-625
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Balderman Sophia R.¹,Li Allison J.²,Hoffman Corey M.³,Frisch Benjamin J.¹,Goodman Alexandra N.⁴,LaMere Mark W.¹,Georger Mary A.⁴,Evans Andrew G.²,Liesveld Jane L.¹,Becker Michael W.¹,Calvi Laura M.⁴^ORCID

Affiliation:

1. Division of Hematology/Oncology, Department of Medicine,

2. Department of Pathology and Laboratory Medicine,

3. Department of Pharmacology and Physiology, and

4. Division of Endocrinology and Metabolism, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY

Abstract

Key Points An in vivo model of MDS displays time-dependent defects in HSPCs and in microenvironmental populations. Normalization of the marrow microenvironment alters disease progression and transformation and improves hematopoietic function.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/127/5/616/1394720/616.pdf

Reference50 articles.

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