Mechanical prophylaxis is a heparin-independent risk for anti–platelet factor 4/heparin antibody formation after orthopedic surgery-Reference-Cited by-同舟云学术

Mechanical prophylaxis is a heparin-independent risk for anti–platelet factor 4/heparin antibody formation after orthopedic surgery

Published:2016-02-25 Issue:8 Volume:127 Page:1036-1043
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Bito Seiji¹²,Miyata Shigeki³,Migita Kiyoshi¹,Nakamura Mashio⁴,Shinohara Kazuhito¹,Sato Tomotaro¹,Tonai Takeharu¹,Shimizu Motoyuki¹,Shibata Yasuhiro¹,Kishi Kazuhiko¹,Kubota Chikara¹,Nakahara Shinnosuke¹,Mori Toshihito¹,Ikeda Kazuo¹,Ota Shusuke¹,Minamizaki Takeshi¹,Yamada Shigeru¹,Shiota Naofumi¹,Kamei Masataka⁵,Motokawa Satoru¹⁶

Affiliation:

1. Japanese National Hospital Organization (NHO)–Evidence-Based Medicine Study Group for the Clinical Study of Prevention and Actual Situation of Venous Thromboembolism After Total Arthroplasty, Tokyo, Japan;

2. Division of Clinical Epidemiology, NHO Tokyo Medical Center, Tokyo, Japan;

3. Division of Transfusion Medicine, National Cerebral and Cardiovascular Center, Osaka, Japan;

4. Department of Cardiology and Nephrology, Mie University Graduate School of Medicine, Mie, Japan;

5. Department of Anesthesiology, National Cerebral and Cardiovascular Center, Osaka, Japan; and

6. Department of Orthopedic Surgery, NHO Nagasaki Medical Center, Nagasaki, Japan

Abstract

Key Points Patients undergoing total knee arthroplasty can develop anti-PF4/heparin antibodies without heparin exposure. Dynamic mechanical prophylaxis is a heparin-independent risk factor for anti-PF4/heparin antibody formation in this patient population.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/127/8/1036/1394819/1036.pdf

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