Targeting casein kinase II restores Ikaros tumor suppressor activity and demonstrates therapeutic efficacy in high-risk leukemia-Reference-Cited by-同舟云学术

Targeting casein kinase II restores Ikaros tumor suppressor activity and demonstrates therapeutic efficacy in high-risk leukemia

Published:2015-10-08 Issue:15 Volume:126 Page:1813-1822
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Song Chunhua¹,Gowda Chandrika¹,Pan Xiaokang¹,Ding Yali¹,Tong Yongqing¹,Tan Bi-Hua¹,Wang Haijun¹,Muthusami Sunil¹,Ge Zheng¹²,Sachdev Mansi¹,Amin Shantu G.³,Desai Dhimant³,Gowda Krishne³,Gowda Raghavendra³,Robertson Gavin P.³,Schjerven Hilde⁴,Muschen Markus⁴,Payne Kimberly J.⁵,Dovat Sinisa¹^ORCID

Affiliation:

1. Department of Pediatrics, Pennsylvania State University College of Medicine, Hershey, PA;

2. Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, China;

3. Department of Pharmacology, Pennsylvania State University College of Medicine, Hershey, PA;

4. Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA; and

5. Department of Pathology and Human Anatomy, Loma Linda University, Loma Linda, CA

Abstract

Key Points Ikaros controls cellular proliferation by repressing genes that regulate cell cycle progression and the PI3K pathway in leukemia. CK2 inhibitor restores Ikaros tumor suppressor function in high-risk B-ALL with IKZF1 deletion and has a strong therapeutic effect in vivo.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/126/15/1813/1389407/1813.pdf

Reference59 articles.

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3. Ikaros is critical for B cell differentiation and function.;Kirstetter;Eur J Immunol,2002

4. Congenital pancytopenia and absence of B lymphocytes in a neonate with a mutation in the Ikaros gene.;Goldman;Pediatr Blood Cancer,2012

5. The Ikaros gene is required for the development of all lymphoid lineages.;Georgopoulos;Cell,1994

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