Neurokinin-1 receptor agonists bias therapeutic dendritic cells to induce type 1 immunity by licensing host dendritic cells to produce IL-12-Reference-Cited by-同舟云学术

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Neurokinin-1 receptor agonists bias therapeutic dendritic cells to induce type 1 immunity by licensing host dendritic cells to produce IL-12

Published:2013-04-11 Issue:15 Volume:121 Page:2923-2933
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Janelsins Brian M.¹²,Sumpter Tina L.¹,Tkacheva Olga A.¹,Rojas-Canales Darling M.³⁴,Erdos Geza¹,Mathers Alicia R.¹²,Shufesky William J.³⁴,Storkus Walter J.¹²⁵,Falo Louis D.¹⁵⁶,Morelli Adrian E.²³⁴,Larregina Adriana T.¹²⁵⁶

Affiliation:

1. Departments of Dermatology,

2. Immunology, and

3. Surgery,

4. Thomas E. Starzl Transplantation Institute,

5. University of Pittsburgh Cancer Institute, and

6. McGowan Center for Regenerative Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, PA

Abstract

Key Points Therapeutic DCs stimulated via NK1R stimulate type 1–biased immunity.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/121/15/2923/1364955/2923.pdf

Reference50 articles.

1. Conceptual development of the immune system as a sixth sense.;Blalock;Brain Behav Immun,2007

2. The inflammatory reflex—introduction.;Andersson;J Intern Med,2005

3. Reflex principles of immunological homeostasis.;Andersson;Annu Rev Immunol,2012

4. Without nerves, immunology remains incomplete -in vivo veritas.;Shepherd;Immunology,2005

5. Sensing the microenvironment of the central nervous system: immune cells in the central nervous system and their pharmacological manipulation.;Fabry;Curr Opin Pharmacol,2008

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