Mononuclear phagocyte miRNome analysis identifies miR-142 as critical regulator of murine dendritic cell homeostasis-Reference-Cited by-同舟云学术

Mononuclear phagocyte miRNome analysis identifies miR-142 as critical regulator of murine dendritic cell homeostasis

Published:2013-02-07 Issue:6 Volume:121 Page:1016-1027
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Mildner Alexander¹,Chapnik Elik²,Manor Ohad³,Yona Simon¹,Kim Ki-Wook¹,Aychek Tegest¹,Varol Diana¹,Beck Gilad²,Itzhaki Zohar Barnett¹,Feldmesser Ester⁴,Amit Ido¹,Hornstein Eran²,Jung Steffen¹

Affiliation:

1. Departments of Immunology,

2. Molecular Genetics,

3. Computer Science and Applied Mathematics, and

4. Biological Services, Weizmann Institute of Science, Rehovot, Israel

Abstract

Key PointsEx vivo isolated myeloid populations of the mononuclear phagocyte network display specific microRNA expression signatures. miR-142–deficient mice display a reduction of splenic CD4+ dendritic cells resulting in impaired priming of CD4 T-cell responses.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/121/6/1016/1368049/zh800613001016.pdf

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