HTLV-1–infected T cells contain a single integrated provirus in natural infection-Reference-Cited by-同舟云学术

HTLV-1–infected T cells contain a single integrated provirus in natural infection

Published:2012-10-25 Issue:17 Volume:120 Page:3488-3490
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Cook Lucy B.¹,Rowan Aileen G.¹,Melamed Anat¹,Taylor Graham P.²,Bangham Charles R. M.¹

Affiliation:

1. Department of Immunology, Wright Fleming Institute, Imperial College London, United Kingdom; and

2. Department of Genito-Urinary Medicine and Communicable Disease, Imperial College London, London, United Kingdom

Abstract

AbstractHuman T lymphotropic virus type 1 (HTLV-1) appears to persist in the chronic phase of infection by driving oligoclonal proliferation of infected T cells. Our recent high-throughput sequencing study revealed a large number (often > 104) of distinct proviral integration sites of HTLV-1 in each host that is greatly in excess of previous estimates. Here we use the highly sensitive, quantitative high-throughput sequencing protocol to show that circulating HTLV-1+ clones in natural infection each contain a single integrated proviral copy. We conclude that a typical host possesses a large number of distinct HTLV-1–infected T-cell clones.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/120/17/3488/1358654/zh804312003488.pdf

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