SOX4 is a direct target gene of FRA-2 and induces expression of HDAC8 in adult T-cell leukemia/lymphoma-Reference-Cited by-同舟云学术

SOX4 is a direct target gene of FRA-2 and induces expression of HDAC8 in adult T-cell leukemia/lymphoma

Published:2013-05-02 Issue:18 Volume:121 Page:3640-3649
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Higuchi Tomonori¹,Nakayama Takashi¹,Arao Tokuzo²,Nishio Kazuto²,Yoshie Osamu¹

Affiliation:

1. Departments of Microbiology and

2. Genome Biology, Kinki University Faculty of Medicine, Osaka, Japan

Abstract

Key Points SOX4 is consistently expressed in ATL, is involved in ATL cell growth, and induces genes such as GCRK, NAP1, and HDAC8 in ATL. FRA-2/JUND and SOX4 form an important oncogenic cascade in ATL, leading to upregulation of genes such as HDAC8.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/121/18/3640/1363108/3640.pdf

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