Simvastatin and t-butylhydroquinone suppress KLF1 and BCL11A gene expression and additively increase fetal hemoglobin in primary human erythroid cells-Reference-Cited by-同舟云学术

Simvastatin and t-butylhydroquinone suppress KLF1 and BCL11A gene expression and additively increase fetal hemoglobin in primary human erythroid cells

Published:2013-01-31 Issue:5 Volume:121 Page:830-839
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Macari Elizabeth R.¹²³⁴,Schaeffer Emily K.¹²³⁴,West Rachel J.¹²³⁴,Lowrey Christopher H.¹²³⁴

Affiliation:

1. Department of Medicine,

2. Department of Pharmacology & Toxicology, and

3. Program in Experimental and Molecular Medicine, Geisel School of Medicine, Dartmouth University, Hanover, NH; and

4. Norris Cotton Cancer Center, Dartmouth-Hitchcock Medical Center, Lebanon, NH

Abstract

Key PointsSimvastatin and tBHQ suppress KLF1 and BCL11 gene expression and additively increase fetal hemoglobin in primary human erythroid cells. Because both drugs are FDA-approved, these findings could lead to clinical trials in the relatively near future.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/121/5/830/1370017/zh800513000830.pdf

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