A novel role of BMP4 in adult hematopoietic stem and progenitor cell homing via Smad independent regulation of integrin-α4 expression-Reference-Cited by-同舟云学术

A novel role of BMP4 in adult hematopoietic stem and progenitor cell homing via Smad independent regulation of integrin-α4 expression

Published:2013-01-31 Issue:5 Volume:121 Page:781-790
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Khurana Satish¹,Buckley Shannon¹,Schouteden Sarah¹,Ekker Stephen²,Petryk Anna³⁴,Delforge Michel⁵,Zwijsen An⁶,Verfaillie Catherine M.¹

Affiliation:

1. Interdepartmental Stem Cell Institute, KU Leuven, Leuven, Belgium;

2. Department of Biochemistry and Molecular Biology, Mayo Clinic Cancer Center, Rochester, MN;

3. Departments of Pediatrics, and

4. Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, MN;

5. Faculty of Medicine, UZ Leuven, Leuven, Belgium; and

6. Department of Developmental and Molecular Genetics, VIB, KU Leuven, Leuven, Belgium

Abstract

Key PointsCytokine-induced loss of murine as well as human HSPC homing during ex vivo culture can be prevented by addition of BMP4. In HSPCs, BMP4 directly regulates Integrin-α4 expression through SMAD-independent p38 MAPK-mediated signaling.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/121/5/781/1370338/zh800513000781.pdf

Reference46 articles.

1. Controlling of bone morphogenetic protein signaling.;Zeng;Cell Signal,2010

2. Smad-dependent and Smad-independent pathways in TGF-beta family signalling.;Derynck;Nature,2003

3. Polarized expression of bone morphogenetic protein-4 in the human aorta-gonad-mesonephros region.;Marshall;Blood,2000

4. Bmpr encodes a type I bone morphogenetic protein receptor that is essential for gastrulation during mouse embryogenesis.;Mishina;Genes Dev,1995

5. Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse.;Winnier;Genes Dev,1995

Cited by 38 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. AML alters bone marrow stromal cell osteogenic commitment via Notch signaling;Frontiers in Immunology;2023-12-04

2. Perivascular niche cells sense thrombocytopenia and activate hematopoietic stem cells in an IL-1 dependent manner;Nature Communications;2023-09-28

3. Inhibition of SRC-mediated integrin signaling in bone marrow niche enhances hematopoietic stem cell function;iScience;2022-10

4. High BMP4 expression in low/intermediate risk BCP-ALL identifies children with poor outcomes;Blood;2022-06-02

5. Age-dependent effects of Igf2bp2 on gene regulation, function, and aging of hematopoietic stem cells in mice;Blood;2022-04-28