Aryl hydrocarbon receptor contributes to the MEK/ERK-dependent maintenance of the immature state of human dendritic cells-Reference-Cited by-同舟云学术

Aryl hydrocarbon receptor contributes to the MEK/ERK-dependent maintenance of the immature state of human dendritic cells

Published:2013-04-11 Issue:15 Volume:121 Page:e108-e117
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Aguilera-Montilla Noemí¹,Chamorro Sonia¹,Nieto Concha¹,Sánchez-Cabo Fátima²,Dopazo Ana²,Fernández-Salguero Pedro Maria³,Rodríguez-Fernández Jose Luis¹,Pello Oscar M.²,Andrés Vicente²,Cuenda Ana⁴,Alonso Bárbara⁵,Domínguez-Soto Angeles¹,Sánchez-Ramón Silvia⁵,Corbí Angel L.¹

Affiliation:

1. Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Científicas (CSIC), Madrid, Spain;

2. Centro Nacional de Investigaciones Cardiovasculares, Madrid, Spain;

3. Universidad de Extremadura, Badajoz, Spain;

4. Centro Nacional de Biotecnología, CSIC, Madrid, Spain;

5. Hospital General Universitario Gregorio Marañón, Madrid, Spain

Abstract

Key Points Aryl hydrocarbon receptor (AhR) mediates the ERK-dependent maintenance of the immature state of monocyte-derived dendritic cells (MDDCs). MEK-ERK regulates antigen capture, lymph node homing, and the acquisition of maturation-associated genes in MDDCs.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/121/15/e108/1366257/e108.pdf

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5. Extracellular signal-regulated protein kinase signaling pathway negatively regulates the phenotypic and functional maturation of monocyte-derived human dendritic cells.;Puig-Kröger;Blood,2001

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