Surface CD107a/LAMP-1 protects natural killer cells from degranulation-associated damage

Author:

Cohnen André12,Chiang Samuel C.3,Stojanovic Ana4,Schmidt Hendrik5,Claus Maren12,Saftig Paul6,Janßen Ottmar5,Cerwenka Adelheid4,Bryceson Yenan T.37,Watzl Carsten12

Affiliation:

1. Leibniz Research Center for Working Environment and Human Factors–IfADo, Dortmund, Germany;

2. Institute for Immunology, University Heidelberg, Heidelberg, Germany;

3. Center for Infectious Medicine, Department of Medicine, Karolinska Institute, Karolinska University Hospital Huddinge, Stockholm, Sweden;

4. Department for Innate Immunity, German Cancer Research Center, Heidelberg, Germany;

5. Unit for Molecular Immunology, Institute for Immunology, and

6. Unit of Molecular Cell Biology and Transgenic Research, Institute of Biochemistry, Eduard Buchner Haus, University Kiel, Kiel, Germany; and

7. Broegelmann Research Laboratory, The Gades Institute, University of Bergen, Bergen, Norway

Abstract

Key Points CD107a protects cytotoxic lymphocytes from damage during degranulation. Interference with CD107a expression can cause the death of cytotoxic lymphocytes during degranulation.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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